MACS Matchmaker
Documentation
Choose a task below or search the manual for assay design, instrument operation, analysis, and troubleshooting guidance.
Start here
Your first measurement, and what the instrument is actually doing.
Run an assay
In the order an experiment happens: surface, design, run, analyze.
Molographic Chips
Guides for preparing chips, including handling, functionalization steps, and quality controls.
How to immobilize my ligand(s)?
Practical guide to choosing an immobilization strategy: amine coupling, capture, click chemistry, and the orientation, density, and reference-channel decisions that shape kinetic data quality.
Backfilling and NSB suppression
What backfilling is, how to choose and tune the backfill probe, and how to verify an affinity-matched chip for measurements in complex media.
Assay Types
What scouting, SCK, MCK, limit of detection and concentration determination each answer, how to plan one, and how it is evaluated, plus the phases a plan is built from.
Experiment Design
Guidelines for setting up common experiment types on the MACS Matchmaker platform.
Instrument Operation
Guidelines for daily operation.
Sensor Regeneration
Choosing, escalating, and scouting a regeneration condition that strips the complex without deactivating the ligand.
Data Analysis
Guidelines for data processing and analysis using the MACS Matchmaker software.
Evaluations
What each evaluation type produces — kinetics, DEL, equilibrium, limit of detection, and concentration prediction — and how to read its findings.
Reference
Biomolecular Interaction Analysis (BIA)
Advanced background on binding theory, kinetics, affinity, and model concepts for users who want deeper scientific context.
Interpreting Results
Choosing a binding model, validating a fit, reading sensorgram artifacts, and reporting kinetic results.
Maintenance & Troubleshooting
Maintenance guidelines, operational issues, troubleshooting and quick recovery steps.
Contact Support
How to reach lino Biotech Support, what to include (serial number, software version, device logs), and how service and repair are arranged.
Safety & Compliance
Regulatory requirements, safety procedures, and compliance checklists for operating the platform.
Appendix
Glossary, abbreviations, the primary literature, and supplemental reference material.
Tools
Selected tools and utilities to use alongside the MACS Matchmaker workflow.