MACS Matchmaker
Interactive simulators for the kinetic and equilibrium binding models used in this platform. Each page shows the governing equation, the assumptions behind the model, and lets you explore how parameters shape the observed response.
Langmuir 1:1
Reversible 1:1 interaction between one analyte and one ligand. The reference model and starting point for kinetic analysis.
4PL Equilibrium (Dose-Response)
Four-parameter logistic curve for steady-state titrations: bottom, top, EC50, Hill slope.
Langmuir 1:2 (Heterogeneous Ligand)
Two independent ligand populations on the same surface — sum of two Langmuirs producing a two-phase response.
Heterogeneous Analyte — Parallel Reactions
Two analyte components in one stable sample mixture contribute different effective 1:1 kinetic phases.
Langmuir 1:1 — Partially Non-Dissociative
Sequential cycles where one shared fraction of bound analyte stays on the surface, raising the baseline cycle by cycle.
Langmuir 1:1 — Injection-Specific Non-Dissociation
Fits a separate non-dissociating fraction for every injection when the residual-to-peak ratio changes across a run.
Langmuir 1:1 — Mass Transport Limited
Analyte must diffuse through a boundary layer before binding. Apparent rate constants drift away from the true ones when transport is the bottleneck.
Langmuir 1:1 — Decaying Surface
Active ligand population decays exponentially over time. Both phases lose binding sites as the run progresses.